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 | |  | | Indiana St. (0-2) | 7 | 0 | 0 | 3 | 10 | | Louisville (1-0) | 3 | 14 | 10 | 3 | 30 |
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| Scoring Summary | | Louisville: Ryan Payne 28 yd FG | | | Indiana St.: Chris Stutzriem 3 yd run (Braulio Martinez kick) | | | Louisville: Bilal Powell 6 yd run (Ryan Payne kick) | | | Louisville: Victor Anderson 6 yd run (Ryan Payne kick) | | | Louisville: Victor Anderson 14 yd run (Ryan Payne kick) | | | Louisville: Ryan Payne 21 yd FG | | | Indiana St.: Braulio Martinez 30 yd FG | | | Louisville: Ryan Payne 31 yd FG | |
| Team Statistics | | | Louisville | Indiana St. | | TOTAL FIRST DOWNS | 22 | 7 | | TOTAL NET YARDS | 419 | 101 | | Total Plays | 65 | 52 | | Average Gain | 6.4 | 1.9 | | NET YARDS RUSHING | 176 | 19 | | Rushes | 30 | 31 | | Average per rush | 5.9 | 0.6 | | NET YARDS PASSING | 243 | 82 | | Completions-attempted | 20-35 | 10-21 | | Sacked | 0 | 2 | | Yards Lost | 0 | -15 | | TOTAL TURNOVERS | 2 | 4 | | Interceptions | 2 | 3 | | Fumbles Lost | 0 | 1 | | OTHER | | | | Penalties | 14 | 9 | | Penalty Yards | 128 | 74 | | Time of Possesion | 31:15 | 28:45 | | Punts | 3 | 5 | | Punt Average | 37 | 41 | | Return Yards | 140 | 143 |
| Passing | | Louisville | CMP | ATT | YDS | TD | INT | YDS/ATT | | | Justin Burke | 17 | 31 | 223 | 0 | 2 | 7.2 | | | Will Stein | 3 | 4 | 20 | 0 | 0 | 5.0 | | | Indiana St. | CMP | ATT | YDS | TD | INT | YDS/ATT | | | Chris Stutzriem | 7 | 15 | 58 | 0 | 2 | 3.9 | | | Travis Johnson | 3 | 6 | 24 | 0 | 1 | 4.0 | |
| Rushing | | Louisville | ATT | YDS | TD | AVG | | | Victor Anderson | 14 | 93 | 2 | 6.6 | | | Bilal Powell | 15 | 76 | 1 | 5.1 | | | Blayne Donnell | 1 | 7 | 0 | 7.0 | | | Indiana St. | ATT | YDS | TD | AVG | | | Antoine Brown | 9 | 14 | 0 | 1.6 | | | Darrius Gates | 10 | 8 | 0 | 0.8 | | | Brock Lough | 2 | 6 | 0 | 3.0 | | | Travis Johnson | 1 | -2 | 0 | -2.0 | | | Chris Stutzriem | 6 | -3 | 1 | -0.5 | | | Reece Craig | 3 | -4 | 0 | -1.3 | |
| Receiving | | Louisville | ATT | YDS | TD | AVG | | | Doug Beaumont | 5 | 69 | 0 | 13.8 | | | Scott Long | 4 | 68 | 0 | 17.0 | | | Cameron Graham | 3 | 43 | 0 | 14.3 | | | Trent Guy | 2 | 15 | 0 | 7.5 | | | Victor Anderson | 2 | 12 | 0 | 6.0 | | | Andrew Robinson | 1 | 16 | 0 | 16.0 | | | Mike Fennerty | 1 | 10 | 0 | 10.0 | | | Bilal Powell | 1 | 6 | 0 | 6.0 | | | Blayne Donnell | 1 | 4 | 0 | 4.0 | | | Indiana St. | ATT | YDS | TD | AVG | | | Larry Lacotti | 3 | 26 | 0 | 8.7 | | | Ryan Roberts | 2 | 24 | 0 | 12.0 | | | Antoine Brown | 2 | 4 | 0 | 2.0 | | | Darrius Gates | 1 | 16 | 0 | 16.0 | | | Jeramie Gray | 1 | 8 | 0 | 8.0 | | | Michael Mardis | 1 | 4 | 0 | 4.0 | |
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